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DOC: P09TYPE: TOOLUPDATED: 2026-11-14VERIFIED: Pharma Packing Machine cGMP Technical Review

Pharmaceutical Blister Web Width, Strokes/Min & Foil Yield Calculator

Calculate blisters per stroke, required web width (mm), punching strokes per minute, and PVC/Alu-Alu + PTP foil kilogram consumption per 100,000 cards.

Size Blister Card Pitch, Multi-Up Dies & Foil Weight Before Ordering Tooling

Cold-form Alu-Alu cavities require wider inter-pocket bridges (6–8 mm) and perimeter seal margins (>=5–6 mm) than thermoformed PVC (3.5–4.5 mm bridges). Grounded in pharma line sizing and compliance and cgmp barrier and validation specs, sizing your card dimensions (L_card × W_card) determines how many cards punch per stroke (N_up), which directly dictates machine frame class (DPP-150 vs DPP-180L vs DPP-260).

Formulas: Web_Width = (N_across × Card_Length_or_Width) + (2 × 8 mm edge trim); Required_Strokes_Min = Target_BPM / (N_up × 0.85_OEE); Foil_Area_m² = (Web_mm × Index_mm × Strokes) / 1,000,000.

ICH stability barrier, footprint, tooling geometry, and cost comparison across Alu-Alu, PVC/PVDC, and HDPE bottles
Hygroscopic molecules marketed in ICH Zone IVb (30 °C / 75% RH) mandate cold-form Alu-Alu or strip foil over plain PVC.

Reference Blister Card Layout & Machine Match Table

Worked formatting examples for standard 10-count (2×5) tablets and capsules:

Dosage & Barrier Typical 10-Ct Card (mm) Cards / Stroke (N_up) Web × Index (mm) Output @ 45 Strokes/Min
8 mm Round Tablet (Alu-PVC) 92 × 38 mm 3-up across 130 × 94 mm 135 blisters/min (~115 net)
Size 0 Capsule (Alu-PVC) 105 × 46 mm 4-up (2×2) 226 × 94 mm (DPP-260) 180 blisters/min (~153 net)
10 mm Tablet (Cold Alu-Alu) 112 × 68 mm 2-up 152 × 114 mm (DPP-180L) 90 blisters/min (~76 net)
Large Caplet (Cold Alu-Alu) 128 × 78 mm 2-up wide 272 × 80 mm (DPP-260/300) 90 blisters/min (~76 net)

Packing into HDPE bottles instead? Size track counts in our tablet counting channel estimator.

Six-stage cGMP balcony blister forming, pinhole/camera inspection, PTP sealing, and serialized cartoning diagram
Balcony construction isolates mechanical drive gears behind a stainless partition away from open tablet feeding zones.

cGMP Cleanroom & Validation Notes

  • Foil Grammage Multipliers (g/m²): 0.25 mm PVC ≈ 345 g/m²; 25 μm PTP lidding foil ≈ 72 g/m²; 25/45/60 Cold-Form Alu-Alu ≈ 240 g/m². Multiply m² per 100k cards (including 10% trim/setup) to budget exact roll orders.
  • Cross-Web Orientation Usually Wins: Orienting the long dimension of the blister card across the web width keeps servo index travel short (70–95 mm), allowing smoother forming dwell times.
  • Keep Cold-Form Strokes <=45–55 CPM on Flat-Plate: Allowing an extra 150 milliseconds of PTFE plug stamping dwell eliminates aluminum corner thinning.

Request a Complimentary CAD Blister Card Drawing

Send your tablet diameter × thickness (or capsule size) and count per card via Project Brief.

Throughput ranges across 8–16 channel bottle counting lines, cold-form Alu-Alu, strip packers, Alu-PVC, and rotary blister lines
Multi-up die punching (2 to 4 blisters per stroke) multiplies blister output per minute at moderate mechanical stroke rates.

Explore related cGMP systems in Pharma Packing Machines, cGMP Barrier & Validation, or send your dosage specs via Project Brief.

Related Specifications

Further Reference

Verify Dimensions & Operating Ratings

Send your target envelope, load requirements, and ambient environment to review matching configurations.